............................................................................................................................. 56 APPENDIXE............................................................................................................................. 59 Survey Questions....................................................................................................................... 60 v

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1. Are you employed by a manufacturer pharmaceutical company in Ireland? o Yes o No

2. What do you consider the level of knowledge of the pharma 4.0 concept in your company? o Zero knowledge o Novice o Basic o Intermediate o Advanced

3. Is there any strategy in place for the implementation of Pharma 4.0 within your company? o No strategy exists. o Pilot initiated. o Strategy in development. o Strategy in implementation. o Strategy implemented.

4. Has your company implemented any of these Pharma 4.0 digital capabilities within their processes? (multiple options can be selected) o Automated processes. o Data acquisition through sensors. o Real Time Data Exchange. o Cloud Data Storage. o Automated data analysis. o Big Data. o Artificial Intelligence. o Internet of things. o PAT tools. o None.

If your previous answer were None or if 1-3 capabilities were selected, please continue with question 5, if not go to question 6.

5. What might be the main reason for the delay in adopting the Pharma 4.0 digital capabilities described previously? Very Likely Likely Unlikely Very Unlikely

Adoption of new Technology

Innovation is not a priority

Cost involved

Regulatory concerns

Data security concerns

Lack of skill workers

Resistance to change